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UNRAVELING THE LANTHANIDE DEPENDENT METABOLIC NETWORK

On a broader scale, we are using system-level approaches (genomics, transcriptomics, metabolomics, and 13C carbon flux studies) along with phenotypic studies of mutants, classic genetic approaches, and microscopic studies to dissect the metabolic network supporting growth when lanthanides are present. We are currently characterizing the mechanism that bacteria uses to sense, solubilize, transport, and store lanthanides.

TEM showing lanthanide storage in the cytoplasm (G panel), and in mutants of transport system (A-E panel), metal analysis (F panel):

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Characterization of the lanthanide utilization and transport system:

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