PUBLICATIONS

>>  Good NM, Fellner M, Demirer K, Hu J, Hausinger RP, Martinez-Gomez NC. (2020) Lanthanide-dependent alcohol dehydrogenases require an essential aspartate residue for metal coordination and enzymatic function. J Biol Chem; 295:8272-8284. doi: 10.1074/jbc.RA120.013227 bioRxiv https://doi.org/10.1101/2020.02.25.964783. 

 

>> Roszczenko-Jasińska, P.; Vu, H.; Subuyuj, G.A.; et al. Martinez-Gomez, N.C*  Skovran, E. (2020) Lanthanide transport, storage, and beyond: genes and processes contributing to XoxF function in Methylorubrum extorquens AM1. Scientific Reports. 10:12633. doi:10.1038/s41598-020-69401-4 bioRxiv  https://doi.org/10.1101/2020.02.25.964783.  * Co-corresponding author

>> Jahn B, Jonasson NSW, Hu H, Pol A, Good NM, Op den Camp HJM, Martinez-Gomez NC, Daumann L. (2020) Understanding the Chemistry of Artificial Electron Acceptors and Redox Dyes – A Study with Lanthanide-Dependent Methanol Dehydrogenases. J Biol Inorg Chem; 25:199-212.  doi: 10.1007/s00775-020-01752-9

>> Skovran E, Raghuraman C, Martinez-Gomez NC. (2019) Lanthanides in Methylotrophy. Curr Issues Mol Biol. 33:101–116. doi:10.21775/cimb.033.101

>> Good NM, Moore RS, Suriano CJ, Martinez-Gomez NC. (2019) Contrasting in vitro and in vivo methanol oxidation activities of lanthanide-dependent alcohol dehydrogenases XoxF1 and ExaF from Methylobacterium extorquens AM1 >> Scientific Reports; 9(1):4248. doi: 10.1038/s41598-019-41043-1. >>  Link    | PDF

>> Hogendoorn C, Roszczenko-Jasińska P, Martinez-Gomez NC., de Graaff J, Grassl P, Pol A, Op den Camp HJM, Daumann LJ.  (2018) Facile Arsenazo III-Based Assay for Monitoring Rare Earth Element Depletion from Cultivation Media for Methanotrophic and Methylotrophic Bacteria. >> Appl Environ Microbiol; 84(8):pii: e02887-17. doi: 10.1128/AEM.02887-17  >>  Link    | PDF

>> Good NM, Vu HN, Suriano CJ, Subuyuj GA, Skovran E, Martinez-Gomez NC. (2016) Pyrroloquinoline Quinone Ethanol Dehydrogenase in Methylobacterium extorquens AM1 Extends Lanthanide-Dependent Metabolism to Multicarbon Substrates. >> J Bacteriol ; 198(22):3109-3118  >>  Link    | PDF

>> Martinez-Gomez NC, Vu HN, Skovran E. (2016) Lanthanide Chemistry:From Coordination in Chemical Complexes Shaping Our Technology to Coordination in Enzymes Shaping Bacterial Metabolism. >> Inorg Chem;  55(20):10083-10089  >>  Link    | PDF                       

>> Agashe D, Sane M, Phalnikar K., Diwan GD, Habibullah A,  Martinez-Gomez NC, Sahasrabuddhe V, Polachek W, Wang J, Chubiz LM, Marx CJ. (2016) Large-Effect Beneficial Synonymous Mutations Mediate Rapid and Parallel Adaptation in a Bacterium. >> Mol Biol Evol; 33(6):1542-53. doi: 10.1093/molbev/msw035  >>  Link   | PDF

>> Vu HN, Subujuj GA,Vijayakumar S, Good NM, Martinez-Gomez NC, Skovran E. (2016) Lanthanide-Dependent Regulation of Methanol Oxidation Systems in Methylobacterium extorquens AM1 and Their Contribution to Methanol Growth. >> J Bacteriol 2016; 198(8):1250-9. doi: 10.1128/JB.00937-15  >>  Link   | PDF

>> Skovran E, Martinez-Gomez NC. (2015) Microbiology. Just add lanthanides. >Science 2015 May 22;348(6237):862-3. doi: 10.1126/science.aaa9091  >> Link  PDF

                  

>>  Good NM, Lee H, Hawker ER, Gilad AA, Martinez-Gomez NC. (2021) Harnessing methylotrophs as a bacterial platform to reduce adverse effects of the use of the heavy lanthanide gadolinium in magnetic resonance imaging. bioRxiv  https://doi.org/10.1101/2021.06.12.448192

>> Good NM, Martinez-Gomez NC. (2021) Expression, purification and testing of lanthanide-dependent enzymes in Methylorubrum extorquens AM1. Methods Enzymol. 650:97-118. doi:10.1016/bs.mie.2021.02.001. PMID:33867027

 
 
Postdoc work 2010-15

>> Martinez-Gomez NC, Good NM, Lidstrom ME. (2015) Methenyl-dephosphotetrahydromethanopterin is a regulatory signal for acclimation to changes in substrate availability in Methylobacterium extorquens AM1. >> J Bacteriol  2015 Jun 15;197(12):2020-6. doi: 10.1128/JB.02595-14  >> Link | PDF

                    

>> Good NM, Lamb A, Beck DAC, Martinez-Gomez NC, Kalyuzhnaya MG. (2015) C1-Pathways in Methyloversatilis universalis FAM5:Genome Wide Gene Expression and Mutagenesis Studies. >> Microorganisms  2015 Apr 9;3(2):175-97. doi: 10.3390/microorganisms3020175  >> Link PDF

 

>> Good NM, Martinez-Gomez NC, Beck DA, Lidstrom ME. (2015) Ethylmalonyl coenzyme A mutase operates as a metabolic control point in Methylobacterium extorquens AM1. >> J Bacteriol  2015 Feb 15;197(4):727-35. doi: 10.1128/JB.02478-14  >>  Link  | PDF

>> Martinez-Gomez NC, Nguyen S, Lidstrom ME. (2013) Elucidation of the role of the methylene-tetrahydromethanopterin dehydrogenase MtdA in the tetrahydromethanopterin- dependent oxidation pathway in Methylobacterium extorquens AM1. >> J Bacteriol 2013 May;195(10):2359-67. doi: 10.1128/JB.00029-13   >>  Link  | PDF

>> Agashe D, Martinez-Gomez NC, Drummond DA, Marx CJ (2013) Good codons, bad transcript: large reductions in gene expression and fitness arising from synonymous mutations in a key enzyme. >> Mol Biol Evol 2013 Mar;30(3):549-60. doi: 10.1093/molbev/mss273  >>  Link   | PDF

Graduate work 2004-09

>> Martinez-Gomez NC, Palmer LD, Vivas E, Roach PL, Downs DM. (2011) The rhodanese domain of Thil is both  necessary and sufficient for synthesis of the thiazole moiety of thiamine in Salmonella enterica. >>   J Bacteriol 2011 Sep;193(18):4582-7. doi: 10.1128/JB.05325-11  >> Link | PDF

>> Martinez-Gomez NC, Poyner RR, Mansoorabadi SO, Reed GH, Downs DM. (2009) Reaction of AdoMet with ThiC generates a backbone free radical.  >>  Biochemistry 2009 Jan 20;48(2):217-9. doi: 10.1021/bi802154j    >> Link   | PDF

>> Martinez-Gomez NC,Downs DM (2008) ThiC is an [Fe-S] cluster protein that requires AdoMet to generate the 4-amino-5 hydroxymethyl-2-methylpyrimidine moiety in thiamin synthesis . >>  Biochemistry 2008 Sep 2;47(35): 9054-6. doi: 10.1021/bi8010253   >>  Link | PDF

>> Martinez-Gomez NC,Downs DM (2004) Mutational analysis of ThiH, a member of the radical S-adenosylmethionine (AdoMet) protein superfamily. >> J Biol Chem   2004 Sep 24;279(39):40505-10  >>   Link | PDF